Abstract
OBJECTIVE: It was our hypothesis that septic illness would alter both protein and energy metabolism in neonates, with elevations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) serving as markers for these effects. STUDY DESIGN: A total of 31 infants with suspected sepsis were enrolled into four groups: septic, sick-nonseptic, healthy-nonseptic, and recovered septic infants. Degree of illness, oxygen consumption, nitrogen balance, urine 3-methylhistidine/creatinine (MeH/Cr), and TNF-α, IL-6, IL-1β, and C-reactive protein (CRP) were measured. RESULTS: Oxygen consumption increased, while nitrogen balance decreased and MeH/Cr increased with increasing degree of illness. Nitrogen balance improved on recovery from sepsis. IL-6 and CRP levels were elevated in septic infants compared with sick-nonseptic and healthy infants. CONCLUSION: Neonates experience a hypermetabolic response with increased nitrogen loss during septic illness, proportional to the degree of illness. Increased delivery of protein substrate may be nutritionally advantageous to the septic neonate.
Original language | English (US) |
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Pages (from-to) | 96-100 |
Number of pages | 5 |
Journal | Journal of Perinatology |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 2000 |
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Effect of sepsis syndrome on neonatal protein and energy metabolism. / Mrozek, Jeanne D.; Georgieff, Michael K; Blazar, Bruce R; Mammel, Mark C; Schwarzenberg, Sarah J.
In: Journal of Perinatology, Vol. 20, No. 2, 01.01.2000, p. 96-100.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of sepsis syndrome on neonatal protein and energy metabolism
AU - Mrozek, Jeanne D.
AU - Georgieff, Michael K
AU - Blazar, Bruce R
AU - Mammel, Mark C
AU - Schwarzenberg, Sarah J
PY - 2000/1/1
Y1 - 2000/1/1
N2 - OBJECTIVE: It was our hypothesis that septic illness would alter both protein and energy metabolism in neonates, with elevations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) serving as markers for these effects. STUDY DESIGN: A total of 31 infants with suspected sepsis were enrolled into four groups: septic, sick-nonseptic, healthy-nonseptic, and recovered septic infants. Degree of illness, oxygen consumption, nitrogen balance, urine 3-methylhistidine/creatinine (MeH/Cr), and TNF-α, IL-6, IL-1β, and C-reactive protein (CRP) were measured. RESULTS: Oxygen consumption increased, while nitrogen balance decreased and MeH/Cr increased with increasing degree of illness. Nitrogen balance improved on recovery from sepsis. IL-6 and CRP levels were elevated in septic infants compared with sick-nonseptic and healthy infants. CONCLUSION: Neonates experience a hypermetabolic response with increased nitrogen loss during septic illness, proportional to the degree of illness. Increased delivery of protein substrate may be nutritionally advantageous to the septic neonate.
AB - OBJECTIVE: It was our hypothesis that septic illness would alter both protein and energy metabolism in neonates, with elevations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) serving as markers for these effects. STUDY DESIGN: A total of 31 infants with suspected sepsis were enrolled into four groups: septic, sick-nonseptic, healthy-nonseptic, and recovered septic infants. Degree of illness, oxygen consumption, nitrogen balance, urine 3-methylhistidine/creatinine (MeH/Cr), and TNF-α, IL-6, IL-1β, and C-reactive protein (CRP) were measured. RESULTS: Oxygen consumption increased, while nitrogen balance decreased and MeH/Cr increased with increasing degree of illness. Nitrogen balance improved on recovery from sepsis. IL-6 and CRP levels were elevated in septic infants compared with sick-nonseptic and healthy infants. CONCLUSION: Neonates experience a hypermetabolic response with increased nitrogen loss during septic illness, proportional to the degree of illness. Increased delivery of protein substrate may be nutritionally advantageous to the septic neonate.
UR - http://www.scopus.com/inward/record.url?scp=0034150829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034150829&partnerID=8YFLogxK
U2 - 10.1038/sj.jp.7200319
DO - 10.1038/sj.jp.7200319
M3 - Article
C2 - 10785884
AN - SCOPUS:0034150829
VL - 20
SP - 96
EP - 100
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 2
ER -