Effect of selective serotonin reuptake inhibitors on cardiovascular morbidity and mortality

Abby E. Von Ruden, David E. Adson, Michael Kotlyar

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Depression in patients with coronary artery disease is associated with increased cardiovascular morbidity and mortality. It is not clear, however, if treatment with selective serotonin reuptake inhibitors (SSRIs) decreases the rate of future cardiovascular events. This paper reviews the available literature regarding the effect of SSRI use on cardiovascular outcomes. Thirteen studies addressing this issue were identified. Of these, 5 concluded that SSRI use is associated with decreased cardiovascular morbidity or mortality, 2 concluded that SSRI use was associated with worsened prognosis, and 6 studies found no statistically significant association. Almost all of the published literature examining the effect of SSRIs on cardiovascular outcomes is based on observational studies, thereby precluding definitive conclusions. Randomized controlled studies are clearly needed to definitively address this issue.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Issue number1
StatePublished - Mar 2008

Bibliographical note

Copyright 2008 Elsevier B.V., All rights reserved.


  • Coronary artery disease
  • Depression
  • Serotonin uptake inhibitors


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