Effect of scopolamine on the cerebral accumulation of 14c-catecholamines from 14c-tyrosine

R. J. Hitzemann, H. H. Loh, E. F. Domino

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6 Scopus citations

Abstract

The effect of the anti-muscarinic and psychotomimetic agent, scopolamine, on the accumulation of 14C- catecholamines formed from 14C-tyrosine administered intra- cerebrally to the mouse was studied. In doses from 3 to 30mg/kg, scopolamine was found to decrease the cerebral accumulation of 14C-dopamine and 14C-norepinephrine but increase the accumulation of 14C-normetanephrine. Similar effects on 14C-catecholamine accumulation were observed when 14C-DOPA was used as substrate. These effects are causally postulated to be related to blockade of inhibitory muscarinic responses which decrease CA output. The relevance of these findings to the toxic psychosis induced by scopolamine is discussed.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalPharmacology
Volume8
Issue number4-6
DOIs
StatePublished - Jan 1 1972

Keywords

  • Brain
  • Catecholamines
  • Catecholamines 14 C-tyrosine Catecholamines
  • Cerebral Scopolamine Psychoses

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