Effect of rate of hemorrhage on release of ACTH in cats

D. A. Bereiter, A. M. Zaid, D. S. Gann

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The effect of rate of blood loss by acute hemorrhage (H) on adrenocorticotropin (ACTH) and cortisol plasma concentrations was assessed in anesthetized cats. Arterial blood was withdrawn at a rapid rate (10% blood vol/min) or at a slow rate (2%/min), and responses were compared across three volumes of H (10, 20, and 30% of blood vol). After rapid rate of H, ACTH increased in proportion to volume of H (r = 0.669, P < 0.001) with a mean elevation of 124 ± 27, 267 ± 102, and 950 ± 195 pg/ml for 10, 20, and 30% H, respectively. Slow rate of H evoked a significant increase in ACTH that was not proportional to volume of H (r = 0.314, P > 0.10), and the mean change during the post-H sampling period was 611 ± 166, 828 ± 302, and 1,070 ± 239 pg/ml for 10, 20, and 30% H, respectively. Control animals showed no change in ACTH to the repeated sampling paradigm. Rapid H evoked an immediate decrease in mean arterial pressure (MAP) with a post-H recovery of MAP inversely proportionate to volume of H (r = -0.552, P < 0.01). Slow H caused a progressive decrease in MAP with no significant post-H recovery of MAP at any volume of H. Cortisol concentration increased in proportion to volume of H after rapid H (r = 0.515, P < 0.025), but not after slow H. The data indicate that 1) rate and volume of blood loss determine the ACTH response to H, 2) recovery of MAP after rapid H may attenuate the increase in ACTH, and 3) an apparent dissociation between the ACTH and cortisol responses to slow H is seen after small volumes of H, but not after large H volumes.

Original languageEnglish (US)
Pages (from-to)13/1
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume250
Issue number1
StatePublished - 1986

Fingerprint Dive into the research topics of 'Effect of rate of hemorrhage on release of ACTH in cats'. Together they form a unique fingerprint.

Cite this