Effect of prenatal vitamin D (calcitriol) exposure on the growth and development of the prostate

Badrinath R. Konety, Ajay K. Nangia, Thu Song T. Nguyen, Angela Thomas, Robert H. Getzenberg

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

BACKGROUND. We previously found that in the absence of testosterone (T), calcitriol promotes proliferation of normal prostatic stroma, while in the presence of T, it has a differentiating effect on prostatic epithelium. The present study was conducted to determine the effect of calcitriol exposure in utero on the postnatal development of the normal prostate. METHODS. Pregnant rats were injected subcutaneously with either l.25 μg of calcitriol or vehicle alone on alternate days till delivery. Calcitriol-exposed and control pups were sacrificed at age 25 days (prepuberty), 63 days (postpuberty), or 102 days (adults), and their prostates and seminal vesicles were harvested find weighed. RESULTS. Pups prenatally exposed to calcitriol and sacrificed before puberty (25 days) had a 35% greater mean prostatic weight than controls (0.0314 vs. 0.0422 g, P < 0.007), and calcitriol-exposed adult rats (102 days) had a 68% greater mean prostatic weight than controls (0.1365 vs. 0.2304 g, P < 0.005). No differences were observed in seminal vesicle weights, and in serum calcium and testosterone levels. A disproportionately high mortality rate from sudden death (71%) was observed at puberty in uncastrated male rats prenatally exposed to calcitriol. CONCLUSIONS. These findings suggest that high-dose calcitriol exposure in utero may uniquely influence subsequent prostatic growth. Nonandrogenic steroids such as calcitriol may also be involved in genetic imprinting of the prostate.

Original languageEnglish (US)
Pages (from-to)181-189
Number of pages9
JournalProstate
Volume41
Issue number3
DOIs
StatePublished - 1999

Keywords

  • Animal experiments
  • Fetal exposure
  • Prostate development
  • Vitamin D

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