Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs

Om P. Sharma; Rajinder K. Dawra; Harinder P.S. Makkar

doi:10.1016/0378-4274(88)90099-9

Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs

Om P. Sharma, Rajinder K. Dawra, Harinder P.S. Makkar

Surgery

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Abstract

A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.

Original language	English (US)
Pages (from-to)	29-37
Number of pages	9
Journal	Toxicology Letters
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(88)90099-9
State	Published - Jul 1988

Keywords

(Guinea pig)
Crystal polymorphism
Lantana
Lantana camara'
Toxin

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abstract = "A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.",

keywords = "(Guinea pig), Crystal polymorphism, Lantana, Lantana camara', Toxin",

author = "Sharma, {Om P.} and Dawra, {Rajinder K.} and Makkar, {Harinder P.S.}",

year = "1988",

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T1 - Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs

AU - Sharma, Om P.

AU - Dawra, Rajinder K.

AU - Makkar, Harinder P.S.

PY - 1988/7

Y1 - 1988/7

N2 - A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.

AB - A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.

KW - (Guinea pig)

KW - Crystal polymorphism

KW - Lantana

KW - Lantana camara'

KW - Toxin

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JO - Toxicology Letters

JF - Toxicology Letters

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ER -

Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs

Abstract

Keywords

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