Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli.

V. Lorian, L. D. Sabath

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.
Original languageUndefined/Unknown
Pages (from-to)754-756
Number of pages3
JournalApplied Microbiology
Volume20
Issue number5
StatePublished - 1970

Keywords

  • Bacteriuria/dt [Drug Therapy]
  • Drug Resistance, Microbial
  • Enterobacteriaceae/de [Drug Effects]
  • Erythromycin/ad [Administration & Dosage]
  • Erythromycin/pd [Pharmacology]
  • Humans
  • Hydrogen-Ion Concentration
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa/de [Drug Effects]

Cite this

Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli. / Lorian, V.; Sabath, L. D.

In: Applied Microbiology, Vol. 20, No. 5, 1970, p. 754-756.

Research output: Contribution to journalArticle

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abstract = "Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14{\%} of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.",
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AU - Sabath, L. D.

PY - 1970

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AB - Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.

KW - Bacteriuria/dt [Drug Therapy]

KW - Drug Resistance, Microbial

KW - Enterobacteriaceae/de [Drug Effects]

KW - Erythromycin/ad [Administration & Dosage]

KW - Erythromycin/pd [Pharmacology]

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Microbial Sensitivity Tests

KW - Pseudomonas aeruginosa/de [Drug Effects]

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VL - 20

SP - 754

EP - 756

JO - Applied Microbiology

JF - Applied Microbiology

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ER -