Abstract
Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 754-756 |
| Number of pages | 3 |
| Journal | Applied Microbiology |
| Volume | 20 |
| Issue number | 5 |
| State | Published - 1970 |
Keywords
- Bacteriuria/dt [Drug Therapy]
- Drug Resistance, Microbial
- Enterobacteriaceae/de [Drug Effects]
- Erythromycin/ad [Administration & Dosage]
- Erythromycin/pd [Pharmacology]
- Humans
- Hydrogen-Ion Concentration
- Microbial Sensitivity Tests
- Pseudomonas aeruginosa/de [Drug Effects]