Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain

Robert J. Hitzemann; Horace H. Loh; Edward F. Domino

doi:10.1016/0024-3205(71)90227-X

Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain

Robert J. Hitzemann, Horace H. Loh, Edward F. Domino

Pharmacology

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Abstract

Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of ¹⁴C-NE formed from ¹⁴C-tyrosine but increased the levels of ¹⁴C-NE formed from ¹⁴C-DOPA. Furthermore, PMA increased the accumulation of ¹⁴C-NM formed from ¹⁴C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.

Original language	English (US)
Pages (from-to)	1087-1095
Number of pages	9
Journal	Life Sciences
Volume	10
Issue number	19 PART 1
DOIs	https://doi.org/10.1016/0024-3205(71)90227-X
State	Published - Oct 1 1971

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title = "Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain",

abstract = "Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of 14C-NE formed from 14C-tyrosine but increased the levels of 14C-NE formed from 14C-DOPA. Furthermore, PMA increased the accumulation of 14C-NM formed from 14C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.",

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AU - Hitzemann, Robert J.

AU - Loh, Horace H.

AU - Domino, Edward F.

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N2 - Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of 14C-NE formed from 14C-tyrosine but increased the levels of 14C-NE formed from 14C-DOPA. Furthermore, PMA increased the accumulation of 14C-NM formed from 14C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.

AB - Para-methoxyamphetamine (PMA) was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10 mg/kg but a significant decrease in these amines was observed at 30 mg/kg. In contrast, all doses of PMA tested markedly elevated brain 5-HT and decreased brain 5-HIAA. PMA caused a dose related decrease in the accumulation of 14C-NE formed from 14C-tyrosine but increased the levels of 14C-NE formed from 14C-DOPA. Furthermore, PMA increased the accumulation of 14C-NM formed from 14C-tyrosine in a manner similar to d-amphetamine. Of the doses tested, only 30 mg/kg of PMA increased psychomotor activity.

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Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain

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