Abstract
Introduction: Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model. Methods: Eighty-six young, middle-aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100 Hz (5 days/week, 8 weeks), sham, or no-implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles. Results: Eight weeks of 100-Hz stimulation resulted in the greatest changes in muscle contractile function with significantly longer contraction and half-decay times, the greatest reduction in fatigue, and a transition toward slowly contracting, fatigue-resistant MyHC isoforms. Discussion: NMES at 100-Hz induced considerable changes in contractile and phenotypic profiles of HG and SG muscles, suggesting higher frequency NMES may yield a greater therapeutic effect. Muscle Nerve, 2018.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 441-448 |
| Number of pages | 8 |
| Journal | Muscle and Nerve |
| Volume | 58 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2018 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 Wiley Periodicals, Inc.
Keywords
- aging
- neuromuscular electrical stimulation
- rodent model
- stimulation frequency
- swallowing disorders
- tongue musculature
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