Effect of Mobile Phase Composition and Highly Fluorinated Bonded Phases on the Apparent Free Energy of Transfer of Solute Functional Groups

Paul C. Sadek, Peter W Carr, Michael J. Ruggio

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The purpose of the present work was to study in detail the chromatographic characteristics of three types of highly fluorinated bonded-phase columns and one analogous hydrocarbonaceous phase in a variety of methanol/water mobile phases. The use of a 42-member, multifunctional solute set enabled the overall direct comparison of these four bonded phases. Particular attention was given to the characterization of the analogous fluorlnated/hydrocarbon bonded phases. These two columns were studied with respect to their retention of members of an homologous series (i.e., through a methylene increment) and a wide variety of functional groups and their overall chromatographic stability In a strongly basic mobile phase (0.01 M sodium hydroxide In 50/50 (v/v) methanol/water).

Original languageEnglish (US)
Pages (from-to)1032-1039
Number of pages8
JournalAnalytical chemistry
Volume59
Issue number7
DOIs
StatePublished - Jan 1 1987

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