Effect of mithramycin on parathyroid hormone production in cancer patients

D. T. Kiang, A. Theologides, A. W. Lindall, B. J. Kennedy

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Mithramycin is an inhibitor of RNA synthesis and may suppress the production of PTH. Following the injection of mithramycin, the serum PTH level was either unchanged or even increased initially. Therefore, the effect of mithramycin in reducing serum calcium is not mediated through the suppression of PTH production. The initial rise in serum PTH in some patients could be due to the release of preformed PTH from the parathyroid gland as a physiological response to the reduction of serum calcium.

Original languageEnglish (US)
Number of pages1
JournalIRCS Medical Science: Biochemistry
Issue number12
StatePublished - Jan 1 1975


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