Effect of microscale mass and heat transport on phase change in tissues and tissue engineered equivalents

David Smith, Ramachandra Devireddy, John Bischof

Research output: Contribution to journalConference articlepeer-review

Abstract

A numerical model for predicting heat and mass transport in biological tissues and tissue engineered equivalents during freezing is developed. The liberation of latent heat due to freezing is assumed to be rate-limited by the cellular-level biophysical processes of water transport and intracellular ice formation. Models for these processes are adopted from the literature to calculate the amount of phase change occurring at each control volume in the tissue domain as a function of temperature and time. The coupled model is applied to a freezing problem, analogous to cryopreservation. The results for both models are very similar in a test case using liver tissue parameters and suggest that the uncoupled approach to numerical solution would be adequate to accurately determine thermal history.

Original languageEnglish (US)
Pages (from-to)S-124
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

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