Effect of Massive Antigen Dosage on Antigen Retention and Antibody Response in Rabbits

Arthur G. Johnson, Dennis W. Watson, William J. Cromartie

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Antigen elimination rates for massive doses of bovine albumin from the circulation of rabbits were resolved into two relative groups: (a) those eliminating the antigen rapidly, and (b) those retaining residual antigen for an extended period. All antibody-forming sites were assumed to be saturated with this antigen, and in the latter group antibody formation was suppressed. Data are presented suggesting that the breakdown and/or removal of an antigen from an antibody-forming site may be a necessary prerequisite to antibody formation. The rates of elimination of antigen from the various organs of the host are discussed in relation to postulated mechanisms concerned with serum sickness and the late sequelae of streptococcal infections.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Mar 1955

Bibliographical note

Funding Information:
This investigation supported by research grant from the National Heart Institute, of the National Institutes of Health, Public Health Service.


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