Effect of marbofloxacin on Haemophilus parasuis nasal carriage

Carles Vilalta, Nuria Galofré, Virginia Aragon, Ana María Pérez de Rozas, Lorenzo Fraile

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Haemophilus parasuis is a colonizer of the upper respiratory tract and the causative agent of Glässer's disease in swine. This study focused on the nasal carriage of H. parasuis after treatment with marbofloxacin. Three marbofloxacin treatments (three doses of 2. mg/kg body weight [bw] every 24. h, two doses of 4. mg/kg bw every 48. h and 8. mg/kg bw in one single shot) were used and all of them reduce significantly (p< 0.05) the nasal carriage of H. parasuis as compared to control animals. Moreover, H. parasuis was not detected in the nasal cavities of piglets after administering the highest dose. The effect of a dose of 8. mg marbofloxacin/kg bw in one shot was further studied in a farm with clinical cases of Glässer's disease using a longitudinal study. Statistically significant reduction of nasal carriage of H. parasuis was detected during the first week after treatment in comparison with the control group. However, a clear relationship between the minimum inhibitory concentration (MIC) of the different strains, their putative virulence or the treatment group (antibiotic or control) from which they were isolated was not detected. Finally, the effect induced by the antibiotic treatment on the bacterial strains seemed to be transitory, since diverse H. parasuis strains (with high and low marbofloxacin MICs) were observed 7. days after finishing the treatment.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalVeterinary Microbiology
Volume159
Issue number1-2
DOIs
StatePublished - Sep 14 2012

Bibliographical note

Funding Information:
This work was partially supported by Grant AGL2010-15232 awarded to Virginia Aragón by the Spanish Ministry of Science and Innovation .

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Antimicrobial treatment
  • Carriage
  • Fluoroquinolones
  • Haemophilus parasuis

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