Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs

Julio Fernandez-Pardal, Leena A. Hilakivi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalAlcohol
Volume6
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Alcohol
  • Behavioral "despair"
  • Desipramine
  • Imipramine
  • Neonatal
  • Nomifensine

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