Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus

Philip R. Schauer, Bartolome Burguera, Sayeed Ikramuddin, Dan Cottam, William Gourash, Giselle Hamad, George M. Eid, Samer Mattar, Ramesh Ramanathan, Emma Barinas-Mitchel, R. Harsha Rao, Lewis Kuller, David Kelley, Michael G. Saar, Michael A. Meguid, Henry Buchwald

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Abstract

Objective: To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). Summary Background Data: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long-term improvement in diabetes in the morbidly obese patient with diabetes. Methods: We evaluated pre- and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. Results: During this 5-year period, 1160 patients underwent LRYGBP and 240 (21%) had IFG or T2DM. Follow up was possible in 191 of 240 patients (80%). There were 144 females (75%) with a mean preoperative age of 48 years (range, 26-67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m 2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60%. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83%) or markedly improved (17%) in all patients. A significant reduction in use of oral antidiabetic agents (80%) and insulin (79%) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic.

Original languageEnglish (US)
Pages (from-to)467-485
Number of pages19
JournalAnnals of surgery
Volume238
Issue number4
StatePublished - Oct 1 2003

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Gastric Bypass
Type 2 Diabetes Mellitus
Weight Loss
Fasting
Glucose
Morbid Obesity
Glycosylated Hemoglobin A
Hypoglycemic Agents
Comorbidity
Body Mass Index
Body Weight
Demography
Insulin
Diet
Weights and Measures

Cite this

Schauer, P. R., Burguera, B., Ikramuddin, S., Cottam, D., Gourash, W., Hamad, G., ... Buchwald, H. (2003). Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus. Annals of surgery, 238(4), 467-485.

Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus. / Schauer, Philip R.; Burguera, Bartolome; Ikramuddin, Sayeed; Cottam, Dan; Gourash, William; Hamad, Giselle; Eid, George M.; Mattar, Samer; Ramanathan, Ramesh; Barinas-Mitchel, Emma; Rao, R. Harsha; Kuller, Lewis; Kelley, David; Saar, Michael G.; Meguid, Michael A.; Buchwald, Henry.

In: Annals of surgery, Vol. 238, No. 4, 01.10.2003, p. 467-485.

Research output: Contribution to journalArticle

Schauer, PR, Burguera, B, Ikramuddin, S, Cottam, D, Gourash, W, Hamad, G, Eid, GM, Mattar, S, Ramanathan, R, Barinas-Mitchel, E, Rao, RH, Kuller, L, Kelley, D, Saar, MG, Meguid, MA & Buchwald, H 2003, 'Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus', Annals of surgery, vol. 238, no. 4, pp. 467-485.
Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G et al. Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus. Annals of surgery. 2003 Oct 1;238(4):467-485.
Schauer, Philip R. ; Burguera, Bartolome ; Ikramuddin, Sayeed ; Cottam, Dan ; Gourash, William ; Hamad, Giselle ; Eid, George M. ; Mattar, Samer ; Ramanathan, Ramesh ; Barinas-Mitchel, Emma ; Rao, R. Harsha ; Kuller, Lewis ; Kelley, David ; Saar, Michael G. ; Meguid, Michael A. ; Buchwald, Henry. / Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus. In: Annals of surgery. 2003 ; Vol. 238, No. 4. pp. 467-485.
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abstract = "Objective: To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). Summary Background Data: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long-term improvement in diabetes in the morbidly obese patient with diabetes. Methods: We evaluated pre- and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. Results: During this 5-year period, 1160 patients underwent LRYGBP and 240 (21{\%}) had IFG or T2DM. Follow up was possible in 191 of 240 patients (80{\%}). There were 144 females (75{\%}) with a mean preoperative age of 48 years (range, 26-67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m 2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60{\%}. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83{\%}) or markedly improved (17{\%}) in all patients. A significant reduction in use of oral antidiabetic agents (80{\%}) and insulin (79{\%}) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: LRYGBP resulted in significant weight loss (60{\%} percent of excess body weight loss) and resolution (83{\%}) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic.",
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AU - Schauer, Philip R.

AU - Burguera, Bartolome

AU - Ikramuddin, Sayeed

AU - Cottam, Dan

AU - Gourash, William

AU - Hamad, Giselle

AU - Eid, George M.

AU - Mattar, Samer

AU - Ramanathan, Ramesh

AU - Barinas-Mitchel, Emma

AU - Rao, R. Harsha

AU - Kuller, Lewis

AU - Kelley, David

AU - Saar, Michael G.

AU - Meguid, Michael A.

AU - Buchwald, Henry

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N2 - Objective: To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). Summary Background Data: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long-term improvement in diabetes in the morbidly obese patient with diabetes. Methods: We evaluated pre- and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. Results: During this 5-year period, 1160 patients underwent LRYGBP and 240 (21%) had IFG or T2DM. Follow up was possible in 191 of 240 patients (80%). There were 144 females (75%) with a mean preoperative age of 48 years (range, 26-67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m 2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60%. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83%) or markedly improved (17%) in all patients. A significant reduction in use of oral antidiabetic agents (80%) and insulin (79%) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic.

AB - Objective: To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). Summary Background Data: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long-term improvement in diabetes in the morbidly obese patient with diabetes. Methods: We evaluated pre- and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. Results: During this 5-year period, 1160 patients underwent LRYGBP and 240 (21%) had IFG or T2DM. Follow up was possible in 191 of 240 patients (80%). There were 144 females (75%) with a mean preoperative age of 48 years (range, 26-67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m 2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60%. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83%) or markedly improved (17%) in all patients. A significant reduction in use of oral antidiabetic agents (80%) and insulin (79%) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic.

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