Abstract
Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.
Original language | English (US) |
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Pages (from-to) | 41-45 |
Number of pages | 5 |
Journal | Toxicology Letters |
Volume | 16 |
Issue number | 1-2 |
DOIs | |
State | Published - Apr 1983 |
Keywords
- Lantana toxicity
- cytosol enzymes
- guinea pig liver
- lysosomal enzymes