Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

O. P. Sharma; H. P.S. Makkar; R. K. Dawra

doi:10.1016/0378-4274(83)90008-5

Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

O. P. Sharma, H. P.S. Makkar, R. K. Dawra

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Abstract

Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.

Original language	English (US)
Pages (from-to)	41-45
Number of pages	5
Journal	Toxicology Letters
Volume	16
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-4274(83)90008-5
State	Published - Apr 1983

Keywords

Lantana toxicity
cytosol enzymes
guinea pig liver
lysosomal enzymes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0378-4274(83)90008-5

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title = "Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver",

abstract = "Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.",

keywords = "Lantana toxicity, cytosol enzymes, guinea pig liver, lysosomal enzymes",

author = "Sharma, {O. P.} and Makkar, {H. P.S.} and Dawra, {R. K.}",

year = "1983",

month = apr,

doi = "10.1016/0378-4274(83)90008-5",

language = "English (US)",

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pages = "41--45",

journal = "Toxicology Letters",

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TY - JOUR

T1 - Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

AU - Sharma, O. P.

AU - Makkar, H. P.S.

AU - Dawra, R. K.

PY - 1983/4

Y1 - 1983/4

N2 - Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.

AB - Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.

KW - Lantana toxicity

KW - cytosol enzymes

KW - guinea pig liver

KW - lysosomal enzymes

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DO - 10.1016/0378-4274(83)90008-5

M3 - Article

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AN - SCOPUS:0020691297

SN - 0378-4274

VL - 16

SP - 41

EP - 45

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1-2

ER -

Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

Abstract

Keywords

UN SDGs

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