Abstract
Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-45 |
| Number of pages | 5 |
| Journal | Toxicology Letters |
| Volume | 16 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Apr 1983 |
Keywords
- Lantana toxicity
- cytosol enzymes
- guinea pig liver
- lysosomal enzymes
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Sharma, O. P., Makkar, H. P. S., & Dawra, R. K. (1983). Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver. Toxicology Letters, 16(1-2), 41-45. https://doi.org/10.1016/0378-4274(83)90008-5