Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

O. P. Sharma, H. P.S. Makkar, R. K. Dawra

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalToxicology Letters
Volume16
Issue number1-2
DOIs
StatePublished - Apr 1983

Keywords

  • Lantana toxicity
  • cytosol enzymes
  • guinea pig liver
  • lysosomal enzymes

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