Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions

Hua Zhao; Olarongbe Olubajo; Zhiyan Song; Artez L. Sims; Terra E. Person; Rasheed A. Lawal; La Dena A. Holley

doi:10.1016/j.bioorg.2005.10.004

Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions

Hua Zhao, Olarongbe Olubajo, Zhiyan Song, Artez L. Sims, Terra E. Person, Rasheed A. Lawal, La Dena A. Holley

Research output: Contribution to journal › Article › peer-review

182 Scopus citations

Abstract

This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF₃COO^- and CH₃COO^-) and chaotropic cations (such as [BuPy]⁺ and [EMIM]⁺), but was destabilized by chaotropic anions (such as tosylate and BF₄ ^-) and kosmotropic cations (such as [BMIM]⁺).

Original language	English (US)
Pages (from-to)	15-25
Number of pages	11
Journal	Bioorganic Chemistry
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.bioorg.2005.10.004
State	Published - Feb 2006
Externally published	Yes

Bibliographical note

Funding Information:
This project was supported by the NIH-EARDA grants (No. 5 G11 HD 32861-07 and No. 5 G11 HD 32861-08). Partial financial support was provided by a NIH-MBRS grant. We are also indebted to Amano Enzyme USA for providing samples of enzymes.

Keywords

Activity
Chaotrope
Enzyme
Ionic liquid
Kosmotrope
Kosmotropicity
Stability

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10.1016/j.bioorg.2005.10.004

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title = "Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions",

abstract = "This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF3COO- and CH3COO-) and chaotropic cations (such as [BuPy]+ and [EMIM]+), but was destabilized by chaotropic anions (such as tosylate and BF4 -) and kosmotropic cations (such as [BMIM]+).",

keywords = "Activity, Chaotrope, Enzyme, Ionic liquid, Kosmotrope, Kosmotropicity, Stability",

author = "Hua Zhao and Olarongbe Olubajo and Zhiyan Song and Sims, {Artez L.} and Person, {Terra E.} and Lawal, {Rasheed A.} and Holley, {La Dena A.}",

note = "Funding Information: This project was supported by the NIH-EARDA grants (No. 5 G11 HD 32861-07 and No. 5 G11 HD 32861-08). Partial financial support was provided by a NIH-MBRS grant. We are also indebted to Amano Enzyme USA for providing samples of enzymes. ",

year = "2006",

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doi = "10.1016/j.bioorg.2005.10.004",

language = "English (US)",

volume = "34",

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T1 - Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions

AU - Zhao, Hua

AU - Olubajo, Olarongbe

AU - Song, Zhiyan

AU - Sims, Artez L.

AU - Person, Terra E.

AU - Lawal, Rasheed A.

AU - Holley, La Dena A.

N1 - Funding Information: This project was supported by the NIH-EARDA grants (No. 5 G11 HD 32861-07 and No. 5 G11 HD 32861-08). Partial financial support was provided by a NIH-MBRS grant. We are also indebted to Amano Enzyme USA for providing samples of enzymes.

PY - 2006/2

Y1 - 2006/2

N2 - This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF3COO- and CH3COO-) and chaotropic cations (such as [BuPy]+ and [EMIM]+), but was destabilized by chaotropic anions (such as tosylate and BF4 -) and kosmotropic cations (such as [BMIM]+).

AB - This paper examined the effect of several pyridinium and imidazolium-based ionic liquids (ILs) on the protease stability in aqueous solutions. In general, the enzyme was found quite active at low concentrations of hydrophilic ILs. In aqueous environment, the enzyme was stabilized by the kosmotropic anions (such as CF3COO- and CH3COO-) and chaotropic cations (such as [BuPy]+ and [EMIM]+), but was destabilized by chaotropic anions (such as tosylate and BF4 -) and kosmotropic cations (such as [BMIM]+).

KW - Activity

KW - Chaotrope

KW - Enzyme

KW - Ionic liquid

KW - Kosmotrope

KW - Kosmotropicity

KW - Stability

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U2 - 10.1016/j.bioorg.2005.10.004

DO - 10.1016/j.bioorg.2005.10.004

M3 - Article

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AN - SCOPUS:31744432116

SN - 0045-2068

VL - 34

SP - 15

EP - 25

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

IS - 1

ER -

Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions

Abstract

Bibliographical note

Keywords

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