TY - JOUR
T1 - Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency
T2 - a randomized interventional trial
AU - Bora, Reeta
AU - Ramasamy, Sutharson
AU - Brown, Benjamin
AU - Wolfson, Julian
AU - Rao, Raghu
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.
AB - Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.
KW - Hemoglobin
KW - motor development
KW - serum ferritin
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U2 - 10.1080/14767058.2019.1638358
DO - 10.1080/14767058.2019.1638358
M3 - Article
C2 - 31258019
AN - SCOPUS:85068779827
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
ER -