Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency

a randomized interventional trial

Reeta Bora, Sutharson Ramasamy, Benjamin Brown, Julian Wolfson, Raghu Rao

Research output: Contribution to journal › Article

Abstract

Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StatePublished - Jan 1 2019

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Iron
Hemoglobins
Ferritins
Mothers
Serum
Child Development
Parturition

Keywords

  • Hemoglobin
  • motor development
  • serum ferritin

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Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency : a randomized interventional trial. / Bora, Reeta; Ramasamy, Sutharson; Brown, Benjamin; Wolfson, Julian; Rao, Raghu.

In: Journal of Maternal-Fetal and Neonatal Medicine, 01.01.2019.

Research output: Contribution to journal › Article

Bora, R, Ramasamy, S, Brown, B, Wolfson, J & Rao, R 2019, 'Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency: a randomized interventional trial', Journal of Maternal-Fetal and Neonatal Medicine. https://doi.org/10.1080/14767058.2019.1638358
Bora R, Ramasamy S, Brown B, Wolfson J, Rao R. Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency: a randomized interventional trial. Journal of Maternal-Fetal and Neonatal Medicine. 2019 Jan 1. https://doi.org/10.1080/14767058.2019.1638358
Bora, Reeta ; Ramasamy, Sutharson ; Brown, Benjamin ; Wolfson, Julian ; Rao, Raghu. / Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency : a randomized interventional trial. In: Journal of Maternal-Fetal and Neonatal Medicine. 2019.
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abstract = "Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.",
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N2 - Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.

AB - Objective: To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency. Study design: Term (37–41 weeks) infants of anemic (Hb ≤ 100 g L−1; N = 100) and non-anemic (Hb > 100 g L−1; N = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg−1 from 36 h of age (N = 50, each of anemic and non-anemic mothers) or no iron-supplementation (N = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups. Results: Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L−1 versus 97.0 ± 9.4 g L−1, p <.0001) and serum ferritin (133.93 ± 52.41 ng mL−1 versus 78.09 ± 42.03 ng mL−1, p <.001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, p <.01). Conclusion: Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.

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