Effect of intraperitoneal bupivacaine on postoperative pain in the gynecologic oncology patient

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9 Scopus citations

Abstract

Study Objective: To evaluate if the administration of intraperitoneal bupivacaine decreased postoperative pain in patients undergoing minimally invasive gynecologic and gynecologic cancer surgery. Design: Retrospective cohort study (Canadian Task Force classification II-3). Setting: University-based gynecologic oncology practice operating at a tertiary medical center. Patients: All patients on the gynecologic oncology service undergoing minimally invasive surgery between September 2011 and June 2013. Interventions: Starting August 2012, intraperitoneal administration of .25% bupivacaine was added to all minimally invasive surgeries. These patients were compared with historical control subjects who had surgery between September 2011 and July 2012 but did not receive intraperitoneal bupivacaine. Measurements and Main Results: One-hundred thirty patients were included in the study. The patients who received intraperitoneal bupivacaine had lower median narcotic use on the day of surgery and the first postoperative day compared with those who did not receive intraperitoneal bupivacaine (day 0: 7.0 mg morphine equivalents vs 11.0 mg, p = .007; day 1: .3 mg vs 1.7 mg, p = .0002). The median patient-reported pain scores were lower on the day of surgery in the intraperitoneal bupivacaine group (2.7 vs 3.2, p = .05). Conclusions: The administration of intraperitoneal bupivacaine was associated with improved postoperative pain control in patients undergoing minimally invasive gynecologic and gynecologic cancer surgery and should be further evaluated in a prospective study.

Original languageEnglish (US)
Pages (from-to)1260-1265
Number of pages6
JournalJournal of Minimally Invasive Gynecology
Volume22
Issue number7
DOIs
StatePublished - 2015

Bibliographical note

Funding Information:
Supported by National Institutes of Health grant P30 CA77598 using the Biostatistics and Bioinformatics Core shared resource of the Masonic Cancer Center, University of Minnesota , and by the National Center for Advancing Translational Sciences of the National Institutes of Health award number UL1TR000114 .

Publisher Copyright:
© 2015 AAGL.

Keywords

  • Bupivacaine
  • Hysterectomy
  • Laparoscopy
  • Local anesthesia
  • Minimally invasive surgery

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