TY - JOUR
T1 - Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calcitonin gene-related peptide
AU - Grutzner, Eric H.
AU - Garry, Mary G.
AU - Hargreaves, Kenneth M.
N1 - Funding Information:
This research was supported in part by NRSA fellowship F32-DE05606 (to M. G. G.).
PY - 1992/11
Y1 - 1992/11
N2 - Neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P are present in dental pulp in relatively high concentrations. Previous studies have demonstrated that the staining density of immunoreactive CGRP (iCGRP) changes in dental pulp after tissue injury. This study evaluated injury-related changes in levels of both immunoreactive CGRP (iCGRP) and immunoreactive substance P (iSP) in dental pulp using radioimmunoassays. After pulpal exposure, iSP levels decreased to about 10% of baseline values, while iCGRP levels decreased to about 45% of baseline measures. After dentin exposure with acid etch, iSP levels decreased to about 10 to 20% of baseline measures, while iCGRP levels decreased to 60% of baseline values. For both forms of injury, iSP decreased to a greater extent than did iCGRP levels. Collectively, these findings indicate that pulpal neuropeptides undergo dynamic, injury-specific, and peptide-specific responses following trauma to dental pulp.
AB - Neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P are present in dental pulp in relatively high concentrations. Previous studies have demonstrated that the staining density of immunoreactive CGRP (iCGRP) changes in dental pulp after tissue injury. This study evaluated injury-related changes in levels of both immunoreactive CGRP (iCGRP) and immunoreactive substance P (iSP) in dental pulp using radioimmunoassays. After pulpal exposure, iSP levels decreased to about 10% of baseline values, while iCGRP levels decreased to about 45% of baseline measures. After dentin exposure with acid etch, iSP levels decreased to about 10 to 20% of baseline measures, while iCGRP levels decreased to 60% of baseline values. For both forms of injury, iSP decreased to a greater extent than did iCGRP levels. Collectively, these findings indicate that pulpal neuropeptides undergo dynamic, injury-specific, and peptide-specific responses following trauma to dental pulp.
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U2 - 10.1016/S0099-2399(06)81213-6
DO - 10.1016/S0099-2399(06)81213-6
M3 - Article
C2 - 1284347
AN - SCOPUS:0026949710
SN - 0099-2399
VL - 18
SP - 553
EP - 557
JO - Journal of Endodontics
JF - Journal of Endodontics
IS - 11
ER -