Effect of influenza vaccination on plasma phenytoin concentrations

Ronald J. Sawchuk, Tom S. Rector, John J. Fordice, Ilo E. Leppik

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A mean decrease in plasma phenytoin concentrations of 11-14% (p < 0.005) was observed in seven patients within 4 days after influenza vaccination. Possible mechanisms are discussed.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalTherapeutic drug monitoring
Issue number2
StatePublished - Jan 1 1979


  • Influenza vaccination
  • Phenytoin
  • Plasma concentration

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