Effect of hypertonic sodium bicarbonate on encainide overdose

Paul R. Pentel, Steven R. Goldsmith, David M. Salerno, Stanley A. Nasraway, David W. Plummer

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Encainide is an experimental type IC antiarrhythmic agent. Experience with acute encainide toxicity is limited. Two fatal overdoses have occurred but both patients died before reaching the hospital (personal communication, M. Cool, Bristol Myers Co., 3 85). We report a case of acute, massive encainide overdose associated with central nervous system and cardiovascular toxicity.

Original languageEnglish (US)
Pages (from-to)878-880
Number of pages3
JournalThe American Journal of Cardiology
Issue number10
StatePublished - Apr 1 1986
Externally publishedYes


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