Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat.

M. R C Greenwood, M. P. Cleary, R. Gruen

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Young Zucker lean (Fa/-) and obese (fa/fa) female rats were fed the fatty acid synthesis inhibitor (-)-hydroxycitrate as a dietary admixture for 39 days. In the lean rats, (-)-hydroxycitrate treatment decreased body weight, food intake, percent of body fat, and fat cell size. In the obese rat, food intake and body weight were reduced but the percent of body fat remained unchanged. Throughout the treatment period, obese rats maintained a fat cell size equivalent to their obese controls. Although a reduction in fat cell number in the obese rats occurred during the treatment period, marked hyperplasia was observed during the posttreatment period. The results of this study indicate that the obese rat, despite a substantial reduction in body weight produced by (-)-hydroxycitrate, still defends its obese body composition.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalThe American journal of physiology
Issue number1
StatePublished - Jan 1981


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