Effect of homatropine eye drops on pain after photorefractive keratectomy: A pilot study

Mahmoud Joshaghani, Hossein Nazari, Khalil Ghasemi Falavarjani, Siamak Shokrollahi, Mohammad Jafar Ghaempanah, Kaveh Abri Aghdam, Zahra Mirbolouk Jalali

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: To assess the effect of homatropine eye drops on pain after photorefractive keratectomy (PRK). Methods: This randomized, double masked, interventional study included 15 patients (30 eyes) who underwent bilateral PRK. After operation, patients received homatropine eye drops, 4 times daily in only one eye (homatropine eye). The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS) and pain rating index (PRI) at 0.5, 24 and 48. h after operation. Results: The level of pain was statistically similar between the two eyes half an hour after operation, however, homatropine eyes had significantly less pain 24. h after operation compared to fellow eyes (2.5 ± 1.9 vs 5.3 ± 2.5, P = 0.004 for VAS, 2.0. ± 1.2 vs 3.2 ± 0.9, P = 0.023 for VRS, and 9.4 ± 5.7 vs 16.0 ± 9.0, P = 0.031 for PRI). Also, 48. h after surgery, the pain scales were less in the homatropine eyes (2.3 ± 1.7 vs 4.0 ± 2.1, P = 0.014 for VAS, 1.6 ± 1.0 vs 2.5 ± 1.0, P = 0.038 for VRS, and 6.8 ± 5.7 vs 12.0 ± 8.9, P = 0.005 for PRI). No delayed epithelial healing was observed. Conclusion: Homatropine eye drops may be useful for reducing pain after Photorefractive keratectomy.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalSaudi Journal of Ophthalmology
Issue number2
StatePublished - Apr 2013
Externally publishedYes


  • Mydriatics
  • Pain
  • Photorefractive keratectomy


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