Effect of high stearic acid containing fat on markers for in vivo lipid peroxidation

A. Saari Csallany, C. M. Seppanen, K. L. Fritz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The objective of this study was to determine the effect of high stearic acid (SA) diets versus high polyunsaturated fatty acid (PUFA) diets on several measures of lipid peroxidation in vivo. Sprague-Dawley rats were fed diets that differed only in the fat source (8% by weight) for 19 weeks. High SA fats were beef tallow (BT) and cocoa butter (CB), high PUFA fats were soybean oil (SO) and menhaden oil (MO). Urine was analyzed for lipophilic aldehydes, the secondary products of lipid peroxidation, by HPLC. Decreases (P < 0.05) were found for 4 nonpolar lipophilic aldehydes and related carbonyl compounds (NPC) and 4 polar lipophilic aldehydes and related carbonyl compounds (PC) when the BT-fed group was compared to the SO-fed groups. Decreases were also found to be significant for total NPC (P <0.01) and total PC (P <0.05) between BTand SO-fed groups. Serum increase in resistance to oxidation (P <0.01) was found in the BT group when compared to the SO group. The differences in urine and serum measurements in the present experiment indicate lower level of lipid peroxidation in vivo due to the consumption of high SA containing BT diet compared to high PUFA containing SO diet without raising serum triglycerides and cholesterol levels significantly for the BT-fed groups.

Original languageEnglish (US)
Pages (from-to)567-579
Number of pages13
JournalInternational Journal of Food Sciences and Nutrition
Issue number8
StatePublished - Dec 2005

Bibliographical note

Funding Information:
Supported in part by the Minnesota Agricultural Experiment Station and the Minnesota Beef Council, Minneapolis, MN. The authors wish to acknowledge Ms. Hyejung Cho for assistance with the animals and other technical assistance.


  • Beef tallow
  • Lipid peroxidation
  • Lipophilic aldehydes
  • Rats
  • Stearic acid
  • Urinary aldehydes

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