Effect of heroin use on changes of brain functions as measured by functional magnetic resonance imaging, a systematic review

Ayman Fareed, Jungjin Kim, Bethany Ketchen, Woo Jin Kwak, Danzhao Wang, Hilaire Shongo-Hiango, Karen Drexler

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In this study the authors focus on reviewing imaging studies that used resting state functional magnetic resonance imaging for individuals with a history of heroin use. This review study compiled existing research addressing the effect of heroin use on decision making by reviewing available functional neuroimaging data. Systematic review of the literatures using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Eligible articles were retrieved through a computer-based MEDLINE and PsycINFO search from 1960 to December 2015 using the major medical subject headings “heroin, fMRI” (all fields). Only English language was included. Thirty-seven articles were initially included in the review. Sixteen were excluded because they did not meet the inclusion criteria. The results of 21 articles that met all the inclusion criteria were presented. Based on the 21 studies included in the current review, there is evidence that heroin use may have a direct and damaging effect on certain brain functions and that these changes may be associated with impulsive and unhealthy decision making. From the review of these studies, the authors understand that a longer duration of heroin use may be associated with more damaging effects on brain functions. The authors also understand that these brain changes could last long after abstinence, which may increase the risk of relapse to heroin use. More research is needed to create a biomarker map for patients with heroin use disorder that can be used to guide and assess response to treatment.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalJournal of Addictive Diseases
Issue number2
StatePublished - Apr 3 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017, This article not subject to US copyright law.


  • Heroin
  • brain
  • fMRI
  • functions


Dive into the research topics of 'Effect of heroin use on changes of brain functions as measured by functional magnetic resonance imaging, a systematic review'. Together they form a unique fingerprint.

Cite this