Effect of hematin in porphyric neuropathy

E. Peter Bosch, Claus A. Pierach, Irene Bossenmaier, Ruth Cardinal, Mark Thorson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable Improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month after the onset of the porphyric relapse had no effect on recovery of the residual neuropathy. We believe hematin may be effective in the treatment of porphyric neuropathy, if administered before irreversible neuronal damage has occurred.

Original languageEnglish (US)
Pages (from-to)1053-1056
Number of pages4
Issue number11
StatePublished - Nov 1977


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