Effect of Ha-ras on mitogen-induced Ca2+- and K+-fluxes

H. Grunicke, K. Maly, M. Meyer, H. Oberhuber, I. Bichler, L. S. Waldegger, E. Woell, F. Lang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Transforming Ha-ras enhances the mitogen-induced activation of both the Ca2+-influx and the furosemide-sensitive Na+/K+/2Cl--cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.

Original languageEnglish (US)
Pages (from-to)163-176
Number of pages14
JournalAdvances in Enzyme Regulation
Issue numberC
StatePublished - 1992
Externally publishedYes

Bibliographical note

Funding Information:
The excellent technical assistance by G. Bunde and E. Kindler is gratefully acknowledged. These studies were supported in part by a grant from the Federal Ministry of Research and Technology of the Federal Republic of Germany as part of the program "Cell biological and biotechnological procedures for the development of anti-tumor agents". These studies were also supported in part by a grant from "D. Swarovski-Leopold-Franzens-Universit/it, Innsbruck F6rderungsfonds".


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