Transforming Ha-ras enhances the mitogen-induced activation of both the Ca2+-influx and the furosemide-sensitive Na+/K+/2Cl--cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.
Bibliographical noteFunding Information:
The excellent technical assistance by G. Bunde and E. Kindler is gratefully acknowledged. These studies were supported in part by a grant from the Federal Ministry of Research and Technology of the Federal Republic of Germany as part of the program "Cell biological and biotechnological procedures for the development of anti-tumor agents". These studies were also supported in part by a grant from "D. Swarovski-Leopold-Franzens-Universit/it, Innsbruck F6rderungsfonds".
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