Effect of Gonadotropin‐Releasing Hormone on Prolactin Levels in Males Unrelated to Stress or Behavioral Changes

WILLIAM R. PHIPPS, SCOTT E. LUKAS, JACK H. MENDELSON, ISAAC SCHIFF

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5 Scopus citations

Abstract

Hormone levels, physiologic parameters, electroencephalographic (EEG) activity, and changes in subjective feelings recorded using a nonverbal instrumental device were assessed following the double‐blind intravenous administration of 500 μg of gonadotropin‐releasing hormone (GnRH) or placebo to five normal males. Within 30 minutes of GnRH administration, prolactin (PRL) levels had risen by 4.3 ± 1.2 ng/ml (mean ± SEM) from a baseline of 8.5 ± 0.9 ng/ml (overall increase P < 0.005 vs. baseline, P < 0.001 vs. placebo); maximally stimulated values had a mean of 16.7 ± 2.3 ng/ml. The PRL elevations measured in absolute terms significantly correlated with increases in luteinizing hormone (LH) (r=0.97) and follicle stimulating hormone (FSH),(r=0.89). No changes in physiologic parameters or EEG activity occurred in response to GnRH, nor were any behavioral responses found. The increase in PRL following GnRH was specifically shown to be unrelated to experimental stress or the behavioral effects of GnRH. 1987 American Society of Andrology

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalJournal of Andrology
Volume8
Issue number4
DOIs
StatePublished - 1987

Keywords

  • gonadotropin‐releasing hormone
  • men
  • prolactin
  • sexual behavior

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