Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians

Ranjana Singh; Abbas Ali Mahdi; Raj Kumar Singh; Cathy Lee Gierke; Germaine Cornelissen

doi:10.1016/j.jab.2018.01.003

Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians

Ranjana Singh, Abbas Ali Mahdi, Raj Kumar Singh, Cathy Lee Gierke, Germaine Cornelissen

Physiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background/Objectives: To determine effects of gender, age, diet, and smoking status on circadian rhythm characteristics of ascorbic acid (vitamin C). Subjects/Methods: Ascorbic acid was measured spectrophotometrically in serum collected from 162 healthy volunteers (103 males and 59 females; 7–75 years) every 6 h for 24 h (4 samples). Data were analyzed by single and population mean cosinor. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple analysis of variance. Results: A circadian rhythm is documented with statistical significance by population mean cosinor. In addition to effects of gender and age, the MESOR is affected by diet and smoking status. The circadian amplitude changes nonlinearly as a function of age. The circadian acrophase advances with increasing age. Conclusion: The present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.

Original language	English (US)
Pages (from-to)	180-185
Number of pages	6
Journal	Journal of Applied Biomedicine
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.jab.2018.01.003
State	Published - Aug 2018

Bibliographical note

Funding Information:
The authors are grateful to the late Professor Franz Halberg, known as the Father of Chronobiology, for his continuous guidance and support in continuation of chronobiological studies. This work was supported by departmental grants (RS, RKS, AAM), and by the Halberg Chronobiology Fund (GC).

Publisher Copyright:
© 2018 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice

Keywords

Age
Ascorbic acid (vitamin C)
Circadian
Diet (vegetarian)
Gender
Smoking

Publisher link

10.1016/j.jab.2018.01.003

Find It

Find It at U of M Libraries

Cite this

@article{cf9728b36c794b66b2de3eead05046b6,

title = "Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians",

abstract = "Background/Objectives: To determine effects of gender, age, diet, and smoking status on circadian rhythm characteristics of ascorbic acid (vitamin C). Subjects/Methods: Ascorbic acid was measured spectrophotometrically in serum collected from 162 healthy volunteers (103 males and 59 females; 7–75 years) every 6 h for 24 h (4 samples). Data were analyzed by single and population mean cosinor. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple analysis of variance. Results: A circadian rhythm is documented with statistical significance by population mean cosinor. In addition to effects of gender and age, the MESOR is affected by diet and smoking status. The circadian amplitude changes nonlinearly as a function of age. The circadian acrophase advances with increasing age. Conclusion: The present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.",

keywords = "Age, Ascorbic acid (vitamin C), Circadian, Diet (vegetarian), Gender, Smoking",

author = "Ranjana Singh and Mahdi, {Abbas Ali} and Singh, {Raj Kumar} and {Lee Gierke}, Cathy and Germaine Cornelissen",

note = "Funding Information: The authors are grateful to the late Professor Franz Halberg, known as the Father of Chronobiology, for his continuous guidance and support in continuation of chronobiological studies. This work was supported by departmental grants (RS, RKS, AAM), and by the Halberg Chronobiology Fund (GC). Publisher Copyright: {\textcopyright} 2018 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice",

year = "2018",

month = aug,

doi = "10.1016/j.jab.2018.01.003",

language = "English (US)",

volume = "16",

pages = "180--185",

journal = "Journal of Applied Biomedicine",

issn = "1214-021X",

publisher = "University of South Bohemia",

number = "3",

}

TY - JOUR

T1 - Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians

AU - Singh, Ranjana

AU - Mahdi, Abbas Ali

AU - Singh, Raj Kumar

AU - Lee Gierke, Cathy

AU - Cornelissen, Germaine

N1 - Funding Information: The authors are grateful to the late Professor Franz Halberg, known as the Father of Chronobiology, for his continuous guidance and support in continuation of chronobiological studies. This work was supported by departmental grants (RS, RKS, AAM), and by the Halberg Chronobiology Fund (GC). Publisher Copyright: © 2018 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice

PY - 2018/8

Y1 - 2018/8

N2 - Background/Objectives: To determine effects of gender, age, diet, and smoking status on circadian rhythm characteristics of ascorbic acid (vitamin C). Subjects/Methods: Ascorbic acid was measured spectrophotometrically in serum collected from 162 healthy volunteers (103 males and 59 females; 7–75 years) every 6 h for 24 h (4 samples). Data were analyzed by single and population mean cosinor. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple analysis of variance. Results: A circadian rhythm is documented with statistical significance by population mean cosinor. In addition to effects of gender and age, the MESOR is affected by diet and smoking status. The circadian amplitude changes nonlinearly as a function of age. The circadian acrophase advances with increasing age. Conclusion: The present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.

AB - Background/Objectives: To determine effects of gender, age, diet, and smoking status on circadian rhythm characteristics of ascorbic acid (vitamin C). Subjects/Methods: Ascorbic acid was measured spectrophotometrically in serum collected from 162 healthy volunteers (103 males and 59 females; 7–75 years) every 6 h for 24 h (4 samples). Data were analyzed by single and population mean cosinor. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple analysis of variance. Results: A circadian rhythm is documented with statistical significance by population mean cosinor. In addition to effects of gender and age, the MESOR is affected by diet and smoking status. The circadian amplitude changes nonlinearly as a function of age. The circadian acrophase advances with increasing age. Conclusion: The present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.

KW - Age

KW - Ascorbic acid (vitamin C)

KW - Circadian

KW - Diet (vegetarian)

KW - Gender

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=85044655771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044655771&partnerID=8YFLogxK

U2 - 10.1016/j.jab.2018.01.003

DO - 10.1016/j.jab.2018.01.003

M3 - Article

AN - SCOPUS:85044655771

SN - 1214-021X

VL - 16

SP - 180

EP - 185

JO - Journal of Applied Biomedicine

JF - Journal of Applied Biomedicine

IS - 3

ER -

Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this