Effect of Gender, Age, Diet and Smoking Status on the Circadian Rhythm of Serum Uric Acid of Healthy Indians of Different Age Groups

Ranjana Singh, Pramod Kumar, Devendra Nath Mishra, Ashok Kumar Singh, Raj Kumar Singh, Abbas Ali Mahdi, Cathy Lee Gierke, Germaine G Cornelissen-Guillaume

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The circadian rhythm of uric acid concentration was studied under near-normal tropical conditions in 162 healthy volunteers (103 males and 59 females; 7 to 75 year). They were mostly medical students, staff members and members of their families. They were classified into 4 age groups: A (7–20 y; N = 42), B (21–40 y; N = 60), C (41–60 y; N = 35) and D (61–75 y; N = 25). They followed a diurnal activity from about 06:00 to about 22:00 and nocturnal rest. Blood samples were collected from each subject every 6 for 24 h (4 samples). Serum uric acid was measured spectrophotometrically. Data from each subject were analyzed by cosinor rhythmometry. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple-analysis of variance. A marked circadian variation was found in uric acid concentration in healthy Indians of all age groups. Furthermore, both the MESOR and circadian amplitude underwent changes with advancing age. In addition to effects of gender and age, diet and smoking were also found to affect the MESOR of circulating uric acid concentration in healthy Indians residing in northern India. The present observations confirmed a definite rhythm in uric acid concentrations with significant effect of gender, age, diet, and smoking status on uric acid concentration in clinical health. Mapping the circadian rhythm of serum uric acid is needed to explore their role in different pathophysiological conditions.

Original languageEnglish (US)
Pages (from-to)164-171
Number of pages8
JournalIndian Journal of Clinical Biochemistry
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Nutrition
Circadian Rhythm
Uric Acid
Age Groups
Smoking
Diet
Serum
Vegetarian Diet
Medical Staff
Analysis of variance (ANOVA)
Medical Students
India
Analysis of Variance
Healthy Volunteers
Blood
Health
Students

Keywords

  • Age
  • Circadian rhythm
  • Diet
  • Epidemiology
  • Gender
  • Healthy population
  • Smoking
  • Uric acid

PubMed: MeSH publication types

  • Journal Article

Cite this

Effect of Gender, Age, Diet and Smoking Status on the Circadian Rhythm of Serum Uric Acid of Healthy Indians of Different Age Groups. / Singh, Ranjana; Kumar, Pramod; Mishra, Devendra Nath; Singh, Ashok Kumar; Singh, Raj Kumar; Mahdi, Abbas Ali; Gierke, Cathy Lee; Cornelissen-Guillaume, Germaine G.

In: Indian Journal of Clinical Biochemistry, Vol. 34, No. 2, 01.04.2019, p. 164-171.

Research output: Contribution to journalArticle

Singh, Ranjana ; Kumar, Pramod ; Mishra, Devendra Nath ; Singh, Ashok Kumar ; Singh, Raj Kumar ; Mahdi, Abbas Ali ; Gierke, Cathy Lee ; Cornelissen-Guillaume, Germaine G. / Effect of Gender, Age, Diet and Smoking Status on the Circadian Rhythm of Serum Uric Acid of Healthy Indians of Different Age Groups. In: Indian Journal of Clinical Biochemistry. 2019 ; Vol. 34, No. 2. pp. 164-171.
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AU - Cornelissen-Guillaume, Germaine G

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AB - The circadian rhythm of uric acid concentration was studied under near-normal tropical conditions in 162 healthy volunteers (103 males and 59 females; 7 to 75 year). They were mostly medical students, staff members and members of their families. They were classified into 4 age groups: A (7–20 y; N = 42), B (21–40 y; N = 60), C (41–60 y; N = 35) and D (61–75 y; N = 25). They followed a diurnal activity from about 06:00 to about 22:00 and nocturnal rest. Blood samples were collected from each subject every 6 for 24 h (4 samples). Serum uric acid was measured spectrophotometrically. Data from each subject were analyzed by cosinor rhythmometry. Effects of gender, age, diet (vegetarian vs. omnivore), and smoking status on the rhythm-adjusted mean (MESOR) and circadian amplitude were examined by multiple-analysis of variance. A marked circadian variation was found in uric acid concentration in healthy Indians of all age groups. Furthermore, both the MESOR and circadian amplitude underwent changes with advancing age. In addition to effects of gender and age, diet and smoking were also found to affect the MESOR of circulating uric acid concentration in healthy Indians residing in northern India. The present observations confirmed a definite rhythm in uric acid concentrations with significant effect of gender, age, diet, and smoking status on uric acid concentration in clinical health. Mapping the circadian rhythm of serum uric acid is needed to explore their role in different pathophysiological conditions.

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KW - Gender

KW - Healthy population

KW - Smoking

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