Effect of gastric acidity on enoxacin absorption

M. E. Lebsack, David Nix, Bruce Ryerson, Roger D. Toothaker, Linda Welage, Allyn M. Norman, Jerome J. Schentag, Allen J. Sedman

Research output: Contribution to journalArticle

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Abstract

The effect of gastric acidity on the oral absorption of the quinolone antibiotic enoxacin was evaluated in 12 healthy volunteers. In a randomized, crossover design, single 400 mg oral enoxacin doses were administered on four occasions: alone, after 50 mg intravenous ranitidine, after 2 µg/kg subcutaneous pentagastrin, and after combined ranitidine and pentagastrin treatment. Gastric pH was monitored by radiotelemetry capsule for 4 hours after enoxacin administration. Ranitidine pretreatment reduced enoxacin oral bioavailability by an average of 26%. This effect was abolished when pentagastrin was used to maintain low gastric pH. Thus the ranitidine‐induced decrease in enoxacin oral bioavailability probably results from a decrease in gastric acidity rather than from an interaction with ranitidine itself. Clinical Pharmacology and Therapeutics (1992) 52, 252–256; doi:

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalClinical Pharmacology & Therapeutics
Volume52
Issue number3
DOIs
StatePublished - Sep 1992

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    Lebsack, M. E., Nix, D., Ryerson, B., Toothaker, R. D., Welage, L., Norman, A. M., Schentag, J. J., & Sedman, A. J. (1992). Effect of gastric acidity on enoxacin absorption. Clinical Pharmacology & Therapeutics, 52(3), 252-256. https://doi.org/10.1038/clpt.1992.138