Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.

Patrick T. Colahan, James E. Bailey, Chi Chung Chou, Martha Johnson, Brett L. Rice, Galin L. Jones, Joseph P. Cheeks

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Twelve clinically sound, healthy, athletically conditioned Thoroughbred horses were subjected to an incremental exercise stress test to determine the effects and period of detection of a single dose of flunixin meglumine (1.1 mg/kg by intravenous injection) in serum and urine by ELISA. Flunixin concentrations, performance, and hematologic and clinical chemical parameters were measured. All horses were rotated through four treatment groups of a Latin-square design providing for each horse to serve as its own control. Flunixin meglumine reduced prostaglandin F(1alpha) and thromboxane concentrations that had been increased by intense exercise. Performance parameters did not improve and prostaglandin concentrations did not significantly correlate with total run time. Exercise did not change the flunixin elimination profile in either serum or urine, and concentrations were found to be below the detection limit of the ELISA test within 36 hours in serum and 120 hours in urine.

Original languageEnglish (US)
Pages (from-to)37-48
Number of pages12
JournalVeterinary therapeutics : research in applied veterinary medicine
Volume3
Issue number1
StatePublished - Mar 1 2002

Fingerprint Dive into the research topics of 'Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test.'. Together they form a unique fingerprint.

Cite this