Abstract
Two peptides, YGAA[KKAAKAA] 2 (AKK), and YG[AKAKAAKA] 2 (KAK) were conjugated with lauric acid and tested for the effect on their structure, antibacterial activity, and eukaryotic cell toxicity. Fatty acid conjugation resulted in an increased ability to permeabilize bacteria membranes for all the peptides. This corresponded to an increase in helical structure in the presence of bacteria-mimicking phospholipid vesicles. The increased ability to permeabilize membranes was accompanied by an increase in antimicrobial activity for the AKK peptide. Investigation into peptide structure in the presence of red blood cell-mimicking phospholipid vesicles show that neither the peptides, nor the fatty acid conjugated peptides have any significant helical structure. Neither the peptides or their fatty acid modified counterparts showed any significant hemolytic activity.
Original language | English (US) |
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Article number | H4.2 |
Pages (from-to) | 271-279 |
Number of pages | 9 |
Journal | Materials Research Society Symposium Proceedings |
Volume | EXS |
Issue number | 1 |
State | Published - 2004 |
Externally published | Yes |
Event | 2003 MRS Fall Meeting - Boston, MA, United States Duration: Dec 1 2003 → Dec 4 2003 |