Effect of dosing and sampling time on serum thyroxine, free thyroxine, and thyrotropin concentrations in dogs following multidose etodolac administration.

Timothy A. Ness, Sheila M. Torres, Elizabeth A. Kramek, Melissa M. Blauvelt

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Thirty-eight dogs with orthopedic disorders received etodolac, an NSAID, at 10.0 to 13.3 mg/kg PO once daily for 14 to 19 days. Mean total thyroxine (T4), free thyroxine (fT4), and canine thyrotropin (cTSH) values before and after etodolac administration were compared using paired t-tests. A significant (P <.05) decrease in T4 values occurred after etodolac administration with 21% of these values falling below the reference range. A significant (P <.05) increase in cTSH following etodolac administration, but none of the values was above the reference range. No significant changes occurred in mean fT4 values; however, 10% of the values fell below the reference range. In conclusion, T4 and fT4 test results should be interpreted with caution in dogs receiving etodolac.

Original languageEnglish (US)
JournalVeterinary therapeutics : research in applied veterinary medicine
Volume4
Issue number4
StatePublished - Dec 2003

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