Effect of dietary nucleotides on immune function in Balb/C mice

Meihong Xu, Ming Zhao, Ruiyue Yang, Zhaofeng Zhang, Yong Li, Junbo Wang

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25 Scopus citations


This study investigated the effect of dietary nucleotides (NTs) on immune function in female Balb/C mice, which randomly distributed into six groups: one control group, one NF-free (NF) control group and four NT groups. NTs ranged from 0.0025% to 0.64%. Compared with the control group, the NF could significantly weaken the activity of T lymphocytes and macrophages, as well as decreased the activity of B lymphocytes and NK cell. NF significantly decreased the ratio of CD4+/CD8+, whereas, it increased Tr percentage. In comparison with the NF group, the concentration of serum IL-2 and IL-4 showed an increase trend. Meanwhile, the granular cell macrophages colony stimulating factor (GM-CSF) increased significantly in the 0.04% NT group. The ratio of Th1/Th2 also showed an increasing trend after the supplements of NTs. There were no significant differences between the control and 0.04% NT group. Nevertheless, no significant differences in weight gain and lymphoid organ indices were observed in our study. These results indicate that NT supplements can prevent hypoimmunity which result from NF diet. 0.04% NTs is the healthy optimal supply proportion in mice diet.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalInternational Immunopharmacology
Issue number1
StatePublished - 2013

Bibliographical note

Funding Information:
The authors are grateful to Zhen-Ao Biotechnology Ltd. for providing the samples of dietary NTs used in this study. This research was supported (grant 2006BAD27B08 ) by the Foundation from the Ministry of Science and Technology of the People's Republic of China .


  • Cytokines
  • Immunomodulatory
  • Mice
  • Nucleotides
  • T subpopulation


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