Effect of dietary fat and omega-3 fatty acids on urinary eicosanoids and sex hormone concentrations in postmenopausal women

A randomized controlled feeding trial

Lindsay R. Young, Mindy S Kurzer, William Thomas, Bruce B Redmon, Susan K. Raatz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Substantial evidence relates increased sex hormone concentrations with increased breast cancer risk. Varying omega-3 (n-3) fatty acid (FA) intake may lead to alterations in eicosanoid balance and changes in circulating sex hormones that reduce risk. To clarify effects of dietary fat and n-3 FA intake on breast cancer risk markers, circulating sex hormones and urinary eicosanoids were measured in response to controlled feeding of diets designed to increase plasma concentrations of n-3 FA. A controlled cross-over feeding trial in postmenopausal women was conducted using 3 diets: high fat (HF; 40% energy from fat), low fat (LF; 20% energy from fat), and low fat plus n-3 FA (LFn3; 20% of energy from fat plus 3% of energy from n-3 FA) in 8-wk feeding periods. Plasma phospholipid fatty acid n-3 increased with the LFn3 relative to HF and LF (P < 0.0001). Plasma estradiol increased by 51% with HF (P = 0.03). Urinary prostaglandin E metabolite increased with HF relative to LF (P = 0.02) and urinary 11-dehydro-thromboxane B2 increased with HF (P = 0.01). These results do not support a role of n-3 FA in the reduction of sex hormone levels.

Original languageEnglish (US)
Pages (from-to)930-939
Number of pages10
JournalNutrition and Cancer
Volume63
Issue number6
DOIs
StatePublished - Aug 1 2011

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Eicosanoids
Dietary Fats
Omega-3 Fatty Acids
Gonadal Steroid Hormones
Randomized Controlled Trials
Fats
Breast Neoplasms
High Fat Diet
Prostaglandins E
Cross-Over Studies
Estradiol
Phospholipids
Diet

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Effect of dietary fat and omega-3 fatty acids on urinary eicosanoids and sex hormone concentrations in postmenopausal women : A randomized controlled feeding trial. / Young, Lindsay R.; Kurzer, Mindy S; Thomas, William; Redmon, Bruce B; Raatz, Susan K.

In: Nutrition and Cancer, Vol. 63, No. 6, 01.08.2011, p. 930-939.

Research output: Contribution to journalArticle

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