Effect of Dibutyryl Cyclic AMP and Serum Deprivation on the Membranes of Transformed Mouse Fibroblasts. A Freeze Fracture Study

Robert E. Scott, Leo T Furcht

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dibutyryl cyclic AMP inhibits growth of certain transformed mouse fibroblasts as does serum starvation. These treatments, however, fail to affect membrane structure as visualized by freeze fracture and electron microscopy. These observations suggest that such treatments do not restore the membranes of transformed cells to normal and that the organization and distribution of certain membrane proteins may be critical for the development and maintenance of the normal contact inhibited state.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume147
Issue number1
DOIs
StatePublished - Oct 1974

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