1. 1. Administration of the 17-ketosteroid, dehydroepiandrosterone (DHEA), to rats results in lowered body weight. 2. 2. A number of changes are seen in livers of treated rats. 3. 3. These include higher liver weights and DNA, RNA and/or protein content, but lowered lipid and glycogen levels. 4. 4. Activities of a number of liver enzymes involved in lipid and carbohydrate metabolism are altered by treatment. 5. 5. In addition, net mitochondrial respiration is elevated by DHEA treatment. 6. 6. Some of these findings may explain DHEA's antiobesity effect.
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Acknowledgemetlls-Supportebdy National Institutes of Health Program Project ResearchG rant HL08214 and by the Hormel Foundation. I thank the many Drexel Universitys tudentsw ho workedo n DHEA relatedp rojects and Dr P. F. Mohan for his contributiont o much of the recentw ork reportedi n this manuscript.