Effect of decreased renal function on the pharmacokinetics of ceftazidime

B. H. Ackerman, J. Ross, R. W. Tofte, J. C. Rotschafer

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).

Original languageEnglish (US)
Pages (from-to)785-786
Number of pages2
JournalAntimicrobial agents and chemotherapy
Issue number6
StatePublished - 1984
Externally publishedYes


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