Effect of decreased renal function on the pharmacokinetics of ceftazidime

B. H. Ackerman; J. Ross; R. W. Tofte; J. C. Rotschafer

doi:10.1128/AAC.25.6.785

Effect of decreased renal function on the pharmacokinetics of ceftazidime

B. H. Ackerman, J. Ross, R. W. Tofte, J. C. Rotschafer

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Abstract

The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).

Original language	English (US)
Pages (from-to)	785-786
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	25
Issue number	6
DOIs	https://doi.org/10.1128/AAC.25.6.785
State	Published - 1984
Externally published	Yes

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AU - Ross, J.

AU - Tofte, R. W.

AU - Rotschafer, J. C.

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AB - The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).

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Effect of decreased renal function on the pharmacokinetics of ceftazidime

Abstract

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