Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine

Robert J. Hitzemann; Horace H. Loh

doi:10.1016/0006-2952(73)90133-0

Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine

Robert J. Hitzemann, Horace H. Loh

Pharmacology

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Abstract

The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of ¹⁴C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of ¹⁴C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of ¹⁴C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.

Original language	English (US)
Pages (from-to)	2731-2741
Number of pages	11
Journal	Biochemical Pharmacology
Volume	22
Issue number	21
DOIs	https://doi.org/10.1016/0006-2952(73)90133-0
State	Published - Nov 1 1973

Bibliographical note

Funding Information:
*This study was supported in part by United States Public Health Service Grant MH-24036 and Army Contract DADA 17-73-C-3127. Dr. H. H. Loh is a recipient of a National Institute of Mental Health Research Scientist Development Award No. K2-DA-70554. t R. Hitzemann and H. Loh, data in preparation. 2731

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title = "Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine",

abstract = "The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.",

author = "Hitzemann, {Robert J.} and Loh, {Horace H.}",

note = "Funding Information: *This study was supported in part by United States Public Health Service Grant MH-24036 and Army Contract DADA 17-73-C-3127. Dr. H. H. Loh is a recipient of a National Institute of Mental Health Research Scientist Development Award No. K2-DA-70554. t R. Hitzemann and H. Loh, data in preparation. 2731",

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T1 - Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine

AU - Hitzemann, Robert J.

AU - Loh, Horace H.

N1 - Funding Information: *This study was supported in part by United States Public Health Service Grant MH-24036 and Army Contract DADA 17-73-C-3127. Dr. H. H. Loh is a recipient of a National Institute of Mental Health Research Scientist Development Award No. K2-DA-70554. t R. Hitzemann and H. Loh, data in preparation. 2731

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N2 - The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.

AB - The effect of acute and chronic d-amphetamine treatment on the synthesis, metabolism and turnover of 14C-choline labeled phosphatidylcholine was measured in discrete regions of the rat brain. Chronic d-amphetamine treatment was found to inhibit the turnover of 14C-phosphatidylcholine in the cortex, cerebellum, hypothalamus, diencephalon, brain stem and caudate nucleus. Acute d-amphetamine treatment was found to inhibit the incorporation of 14C-choline into phosphatidylcholine only in the cortex and cerebellum. Studies in vitro suggest that d-amphetamine inhibits cortical phosphatidylcholine synthesis at the cytidine diphosphorylcholine diglyceride transferase step. d-Amphetamine was not found to alter the base-exchange reaction or phospholipase C activity.

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ER -

Effect of d-amphetamine on the turnover, synthesis and metabolism of brain phosphatidylcholine

Abstract

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