Effect of d-amphetamine on brain protein synthesis

H. Loh, R. Hitzemann, S. Stolman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The effect of high to lethal doses of d-amphetamine on the incorporation of radiolabeled leucine into brain microsomal protein was studied in mice. High doses of d-amphetamine ranging from 30 to 100 mg/kg significantly inhibited protein synthesis 1 hr after ip injection, whereas smaller doses were ineffective. The addition of d-amphetamine to the microsomal incubation system at concentrations greater than 5 mm likewise inhibited protein synthesis. The in vivo and in vitro inhibitory effect was attributed to a drug-induced alteration of the soluble fraction rather than of the brain microsomes.

Original languageEnglish (US)
Pages (from-to)476-481
Number of pages6
JournalToxicology and Applied Pharmacology
Issue number3
StatePublished - Nov 1973

Bibliographical note

Funding Information:
1 This investigation was supported in part by U.S. Army Medical Research and Development Command under Contract No. DADA1 7-73-C-31 27. * Present address: Department of Pharmacology, Michigan State University, East Lansing, Michigan.


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