Effect of cyclic 3',5' AMP on the (Na+K) ATPase of myocardial sarcolemma

C. J. Limas; A. V. Notargiacomo; J. N. Cohn

Effect of cyclic 3',5' AMP on the (Na+K) ATPase of myocardial sarcolemma

C. J. Limas
, A. V. Notargiacomo
, J. N. Cohn

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A dose related inhibition of the (Na + K) ATPase of canine heart sarcolemma was found in the presence of cyclic 3',5' AMP (maximal inhibition at 10^-4 M cyclic AMP), while 5' AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca⁺⁺ stimulated ATPase.

Original language	English (US)
Pages (from-to)	477-481
Number of pages	5
Journal	Cardiovascular Research
Volume	7
Issue number	4
State	Published - Dec 1 1973

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title = "Effect of cyclic 3',5' AMP on the (Na+K) ATPase of myocardial sarcolemma",

abstract = "A dose related inhibition of the (Na + K) ATPase of canine heart sarcolemma was found in the presence of cyclic 3',5' AMP (maximal inhibition at 10-4 M cyclic AMP), while 5' AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca++ stimulated ATPase.",

author = "Limas, \{C. J.\} and Notargiacomo, \{A. V.\} and Cohn, \{J. N.\}",

year = "1973",

month = dec,

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language = "English (US)",

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journal = "Cardiovascular Research",

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T1 - Effect of cyclic 3',5' AMP on the (Na+K) ATPase of myocardial sarcolemma

AU - Limas, C. J.

AU - Notargiacomo, A. V.

AU - Cohn, J. N.

PY - 1973/12/1

Y1 - 1973/12/1

N2 - A dose related inhibition of the (Na + K) ATPase of canine heart sarcolemma was found in the presence of cyclic 3',5' AMP (maximal inhibition at 10-4 M cyclic AMP), while 5' AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca++ stimulated ATPase.

AB - A dose related inhibition of the (Na + K) ATPase of canine heart sarcolemma was found in the presence of cyclic 3',5' AMP (maximal inhibition at 10-4 M cyclic AMP), while 5' AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca++ stimulated ATPase.

UR - https://www.scopus.com/pages/publications/0015781474

UR - https://www.scopus.com/pages/publications/0015781474#tab=citedBy

M3 - Article

C2 - 4352843

AN - SCOPUS:0015781474

SN - 0008-6363

VL - 7

SP - 477

EP - 481

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 4

ER -

Effect of cyclic 3',5' AMP on the (Na+K) ATPase of myocardial sarcolemma

Abstract

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