Effect of cyclic 3',5'-AMP on the (Na + K)-ATPase of myocardial sarcolemma

C. J. Limas, A. V. Notargiacomo, J. N. Cohn

Research output: Contribution to journalArticlepeer-review


AUTHORS' SYNOPSIS: A dose-related inhibition of the (Na+K)-ATPase of canine heart sarcolemma was found in the presence of cyclic 3', 5'-AMP (maximal inhibition at 10 -4 M cyclic AMP), while 5'-AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca+ +-stimulated ATPase.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalCardiovascular Research
Issue number4
StatePublished - Jan 1 1973


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