Effect of cyclic 3',5'-AMP on the (Na + K)-ATPase of myocardial sarcolemma

C. J. Limas; A. V. Notargiacomo; J. N. Cohn

doi:10.1093/cvr/7.4.477

Effect of cyclic 3',5'-AMP on the (Na + K)-ATPase of myocardial sarcolemma

C. J. Limas, A. V. Notargiacomo, J. N. Cohn

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

Abstract

AUTHORS' SYNOPSIS: A dose-related inhibition of the (Na+K)-ATPase of canine heart sarcolemma was found in the presence of cyclic 3', 5'-AMP (maximal inhibition at 10 ^-4 M cyclic AMP), while 5'-AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca⁺ ⁺-stimulated ATPase.

Original language	English (US)
Pages (from-to)	477-481
Number of pages	5
Journal	Cardiovascular Research
Volume	7
Issue number	4
DOIs	https://doi.org/10.1093/cvr/7.4.477
State	Published - Jan 1 1973

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abstract = "AUTHORS' SYNOPSIS: A dose-related inhibition of the (Na+K)-ATPase of canine heart sarcolemma was found in the presence of cyclic 3', 5'-AMP (maximal inhibition at 10 -4 M cyclic AMP), while 5'-AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca+ +-stimulated ATPase.",

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year = "1973",

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AB - AUTHORS' SYNOPSIS: A dose-related inhibition of the (Na+K)-ATPase of canine heart sarcolemma was found in the presence of cyclic 3', 5'-AMP (maximal inhibition at 10 -4 M cyclic AMP), while 5'-AMP did not affect the enzyme. A similar inhibition of the ATPase was seen after incubation of the sarcolemma preparation with NaF adrenaline and theophylline. None of these substances affected the activity of the Ca+ +-stimulated ATPase.

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