Chromatins have been isolated from both placebo- and chronic morphine-treated mice. The specific activity of chromatin-directed UTP incorporation was measured. Evidence is presented to show that the chromatin template activity isolated from tolerant animals is increased. The increase may be due to the alteration of non-histone protein in chromatin. This is a narcotic-specific phenomenon, since the morphine-induced increase can be blocked by naloxone.
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Acknowledgements These studies were supported in part by NIMH grants DA-00563 and DA-00564 and U.S. Army Research Contract DADA-17-73-C-3006.