Effect of cholestyramine and colestipol on the absorption of phenytoin

J. T. Callaghan; M. Tsuru; J. L. Holtzman; D. B. Hunninghake

doi:10.1007/BF00542221

Effect of cholestyramine and colestipol on the absorption of phenytoin

J. T. Callaghan, M. Tsuru, J. L. Holtzman, D. B. Hunninghake

University of Minnesota Twin Cities

Research output: Contribution to journal › Article › peer-review

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Abstract

The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

Original language	English (US)
Pages (from-to)	675-678
Number of pages	4
Journal	European Journal of Clinical Pharmacology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1007/BF00542221
State	Published - Sep 1 1983

Keywords

cholestyramine
clearance
colestipol
phenytoin absorption

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10.1007/BF00542221

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title = "Effect of cholestyramine and colestipol on the absorption of phenytoin",

abstract = "The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.",

keywords = "cholestyramine, clearance, colestipol, phenytoin absorption",

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T1 - Effect of cholestyramine and colestipol on the absorption of phenytoin

AU - Callaghan, J. T.

AU - Tsuru, M.

AU - Holtzman, J. L.

AU - Hunninghake, D. B.

PY - 1983/9/1

Y1 - 1983/9/1

N2 - The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

AB - The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

KW - cholestyramine

KW - clearance

KW - colestipol

KW - phenytoin absorption

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JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

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ER -

Effect of cholestyramine and colestipol on the absorption of phenytoin

Abstract

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