Effect of castration on metalloprotease activities in the lateral, dorsal, and anterior lobes of the rat prostate

M. J. Wilson, H. Norris, M. Woodson, A. A. Sinha

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Several proteolytic enzymes are involved in mediating the regression of the prostate gland following castration. A previous study showed that plasminogen activator activities are elevated only in the ventral lobe by castration in the rat. Since matrix metalloproteases represent a different class of protease that degrade extracellular matrix, this study examined their activities in the lateral, dorsal, and anterior lobes of the rat in response to androgen deprivation. The results indicate that, in contrast to plasminogen activators, metalloprotease activities are increased in the lateral, dorsal, and anterior lobes following orchiectomy. This suggests that differences in regulation of certain proteases by androgens may occur in individual prostatic lobes.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalArchives of Andrology
Volume35
Issue number2
DOIs
StatePublished - 1995

Keywords

  • Metalloprotease
  • Prostate
  • Type IV collagenase

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