Effect of calcitonin gene-related peptide on well-developed canine coronary collateral vasculature

Brian B. Quebbeman, Daniel Dulas, John Altman, David C. Homans, Robert J Bache

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This study was performed to examine the effect of calcitonin gene-related peptide (CGRP) on blood flow through well-developed coronary collateral vessels. Studies were performed in 9 adult mongrel dogs 4-6 months after embolic occlusion of the left anterior descending coronary artery (LAD) with a hollow intravascular plug to stimulate collateral vessel growth. At the time of study, the LAD was cannulated to determine interarterial collateral flow from measurement of retrograde blood flow. Radioactive microspheres were injected during retrograde flow collection to determine continuing tissue flow in the collateral dependent region. CGRP was infused into the left main coronary artery in a dose of 0.2 μg/kg/min to reach collateral vessels originating from the left coronary system. Retrograde blood flow was 40 ± 9 ml/min during basal conditions and increased 22 ± 9% in response to infusion of CGRP (n = 9, p < 0.05). Tissue flow to the collateral-dependent myocardial region did not change in response to CGRP infusion. Isolated rings of epicardial collateral vessels contracted with prostaglandin F(PGF) underwent relaxation in response to CGRP which was similar in magnitude to that of normal coronary arteries of comparable size. These data demonstrate that CGRP causes vasodilation of well-developed epicardial coronary collateral vessels, resulting in an increase in collateral blood flow.

Original languageEnglish (US)
Pages (from-to)774-780
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume21
Issue number5
DOIs
StatePublished - May 1993

Keywords

  • Calcitonin gene-related peptide
  • Collateral blood flow
  • Coronary collateral vessels
  • Dog
  • Vasodilation

Fingerprint Dive into the research topics of 'Effect of calcitonin gene-related peptide on well-developed canine coronary collateral vasculature'. Together they form a unique fingerprint.

Cite this