Effect of caffeine on the ventilatory response to inhaled carbon dioxide

Paul Pianosi; Danielle Grondin; Katherine Desmond; Allan L. Coates; Jacob V. Aranda

doi:10.1016/0034-5687(94)90093-0

Effect of caffeine on the ventilatory response to inhaled carbon dioxide

Paul Pianosi, Danielle Grondin, Katherine Desmond, Allan L. Coates, Jacob V. Aranda

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. Pet_CO₂ and (V̇e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the V̇e-Pet_CO₂ response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min^-1·mmHg^-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs Pet_CO₂ revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-Pet_CO₂ relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO₂ interaction is dependent on the methodology employed.

Original language	English (US)
Pages (from-to)	311-320
Number of pages	10
Journal	Respiration Physiology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(94)90093-0
State	Published - Mar 1994
Externally published	Yes

Keywords

CO response
Control of breathing
Mammals
Pharmacological agents
caffeine
humans
steady state vs rebreathing

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10.1016/0034-5687(94)90093-0

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title = "Effect of caffeine on the ventilatory response to inhaled carbon dioxide",

abstract = "We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PetCO2 and ({\.V}e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the {\.V}e-PetCO2 response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min-1·mmHg-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs PetCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-PetCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.",

keywords = "CO response, Control of breathing, Mammals, Pharmacological agents, caffeine, humans, steady state vs rebreathing",

author = "Paul Pianosi and Danielle Grondin and Katherine Desmond and Coates, \{Allan L.\} and Aranda, \{Jacob V.\}",

year = "1994",

month = mar,

doi = "10.1016/0034-5687(94)90093-0",

language = "English (US)",

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pages = "311--320",

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TY - JOUR

T1 - Effect of caffeine on the ventilatory response to inhaled carbon dioxide

AU - Pianosi, Paul

AU - Grondin, Danielle

AU - Desmond, Katherine

AU - Coates, Allan L.

AU - Aranda, Jacob V.

PY - 1994/3

Y1 - 1994/3

N2 - We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PetCO2 and (V̇e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the V̇e-PetCO2 response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min-1·mmHg-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs PetCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-PetCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.

AB - We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PetCO2 and (V̇e), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the V̇e-PetCO2 response increased from 0.21 ± 0.14 to 0.38 ± 0.14 and from 0.23 ± 0.12 to 0.59 ± 0.45 VC·min-1·mmHg-1, measured by RB and SS respectively (P<0.05). Plotting Vt vs PetCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the Vt-PetCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.

KW - CO response

KW - Control of breathing

KW - Mammals

KW - Pharmacological agents

KW - caffeine

KW - humans

KW - steady state vs rebreathing

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U2 - 10.1016/0034-5687(94)90093-0

DO - 10.1016/0034-5687(94)90093-0

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SN - 0034-5687

VL - 95

SP - 311

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JO - Respiration Physiology

JF - Respiration Physiology

IS - 3

ER -

Effect of caffeine on the ventilatory response to inhaled carbon dioxide

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